Organization
Profluent
Model developer · Research lab · Emeryville, California
Profluent is a company in Emeryville, California that trains protein language models and uses them to design proteins, starting with gene editors. Its public releases include the ProGen3 generative models under a non-commercial weights license, the Profluent-E1 encoder models under a permissive license with attribution requirements, and the AI-designed OpenCRISPR-1 gene editor.12457
Using this organization’s offerings
The detailed audience, self-hosting, pricing, and restrictions review has not yet been completed. Consult the sourced product records below and the publisher’s current terms. Missing detail means unknown, not unavailable.
Key facts
- Ownership (separate from openness)
- Privately held
Recorded classification; fact-level ownership verification pending.
- Legal form
- Unknown
- Headquarters
- Emeryville, California1
- Founded
- Unknown
- Sectors
- Science, Open models, Research
What is and isn’t public
Profluent's public model weights carry different terms: Profluent-E1 weights are under a custom clickthrough license that permits commercial use with attribution requirements, while ProGen3 and protein2pam weights are under non-commercial Creative Commons licenses. Its partnered work and API are not public releases. See the Profluent-E1 record.87563
Products
No product records yet.
Cataloged artifacts
Model families
- Profluent-E1Model family
Model releases
- Profluent-E1 150M (E1-150m)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
- Profluent-E1 300M (E1-300m)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
- Profluent-E1 600M (E1-600m)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
Notable documented facts
- Profluent released OpenCRISPR-1, an AI-generated Cas9-like gene editor, as an open-source initiative that is freely available to license for ethical research and commercial uses; access is requested through a form. OpenCRISPR-1 is a protein design, not a model release.2
- ProGen3 code is released under Apache 2.0 and its six model checkpoints (112M to 3B parameters) under CC BY-NC-SA 4.0, a non-commercial license. Profluent's ProGen3 announcement directs partners to license its molecule assets or join early API access.563
- In September 2025 Profluent published protein2pam checkpoints on Hugging Face under CC BY-NC 4.0.6
Open positions
Automated job coverage is not configured for this organization.
What this catalog does not know
- Founding date: not documented in the sources reviewed.
- Products: none documented in this record.
Have a primary source? How to report a correction.
U.S. eligibility
Eligible · basis: U.S. headquarters
Profluent's website terms identify Profluent Bio Inc. as the website operator with a notice address in Emeryville, California, and choose California law with venue in Alameda County. The Profluent-E1 license also names Profluent Bio Inc. and California law. No regulatory filing was reviewed.18
Sources
This listing is not an endorsement or a federal approval.