Model family
Profluent-E1
Family overview — summarizes releases; licenses and availability belong to each release.
Profluent-E1 is a family of protein encoder language models from Profluent, announced in November 2025 in 150M, 300M, and 600M parameter sizes. The models can take homologous sequences alongside a query sequence (retrieval augmentation) or run on a single sequence, and Profluent presents them as drop-in replacements for ESM-family encoders.514
- Repository: GitHub repository (Profluent-AI/E1) (external site: github.com)
- Model hub: E1-600m weights (Hugging Face) (external site: huggingface.co)
- License: Profluent-E1 Clickthrough License Agreement (external site: github.com)
- Release notes: Profluent-E1 announcement (external site: profluent.bio)
- Paper: Profluent-E1 preprint (bioRxiv 2025.11.12.688125) (external site: biorxiv.org)
Last reviewedEntry updated Documented release
Releases assessed
Each release is assessed on its own. This family has no family-wide openness label.
| Release | Weights | Tier (USASI rubric v0.2) | License | Released |
|---|---|---|---|---|
| Profluent-E1 150M (E1-150m) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | Profluent-E1 Clickthrough License Agreement, Apache-2.0 | Nov 13, 2025 |
| Profluent-E1 300M (E1-300m) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | Profluent-E1 Clickthrough License Agreement, Apache-2.0 | Nov 13, 2025 |
| Profluent-E1 600M (E1-600m) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | Profluent-E1 Clickthrough License Agreement, Apache-2.0 | Nov 13, 2025 |
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