ether0
Family overview — summarizes releases; licenses and availability belong to each release.
Maintained by FutureHouse134
ether0 is a 24B-parameter chemistry reasoning model from FutureHouse, released in June 2025. It reasons in English and answers with molecular structures written as SMILES. It was fine-tuned and trained with reinforcement learning from Mistral AI's Mistral-Small-24B-Instruct-2501.142
- Model hub: Model card and weights (Hugging Face) (external site: huggingface.co)
- Repository: Reward functions and utilities (GitHub) (external site: github.com)
- Dataset hub: ether0 benchmark (Hugging Face dataset) (external site: huggingface.co)
- Release notes: FutureHouse announcement (external site: futurehouse.org)
- Paper: Training a Scientific Reasoning Model for Chemistry (arXiv 2506.17238) (external site: arxiv.org)
Releases assessed
| Release | Weights | Tier (USASI rubric v0.2) | License | Released |
|---|---|---|---|---|
| ether0 (24B) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | Apache-2.0, Apache-2.0 | Jun 4, 2025 |
What it is useful for
The model card lists molecule-design and prediction tasks it was trained for, including IUPAC name or formula to SMILES, adjusting solubility, pKa, or scent, ADME and toxicity properties, one-step retrosynthesis, reaction outcome prediction, and molecule captioning in reverse. The card says it is not a general-purpose chat model.1
Organization context
U.S. eligibility
Eligible · basis: U.S.-governed project
ether0 is published by FutureHouse on its Hugging Face and GitHub organizations, and the model card states a 2025 FutureHouse copyright. FutureHouse is a 501(c)(3) nonprofit in San Francisco per its about page and the IRS exempt-organization extract. The base model, Mistral-Small-24B-Instruct-2501, comes from Mistral AI and is recorded as provenance on the release record, not as a U.S. model.1356
Sources
This listing is not an endorsement, a safety assessment, or a federal approval.