Organization
Biohub (Chan Zuckerberg Biohub)
Biohub (Chan Zuckerberg Biohub) is a research lab and nonprofit research organization headquartered in Redwood City, California419. This catalog lists 2 open model releases from Biohub (Chan Zuckerberg Biohub), under licenses including the MIT License.
Documented roles: Research lab · Nonprofit research
Biohub is a biomedical research organization, founded in 2016 and supported by the Chan Zuckerberg Initiative, that builds AI models of biology alongside data-generation, imaging, and laboratory technologies. After announcing in November 2025 that the EvolutionaryScale team would join it, Biohub now publishes the ESM protein models and runs the Biohub Platform for using them.1326
Using this organization’s offerings
The detailed audience, self-hosting, pricing, and restrictions review has not yet been completed. Consult the sourced product records below and the publisher’s current terms. Missing detail means unknown, not unavailable.
Key facts
- Ownership (separate from openness)
- Nonprofit
Recorded classification; fact-level ownership verification pending.
- Legal form
- Corporation recognized by the IRS as tax-exempt under Section 501(c)(3); the IRS extract classifies it as a hospital or medical research organization under section 170(b)(1)(A)(iii).910
- Founded
- 20161
- Sectors
- Science, Research
What is and isn’t public
Products
Hosted model products
Labeled Hosted product/API — this describes how a documented product is delivered (hosted access). It does not determine whether underlying weights or code are open; assess the specific release and its licenses.
| Product | Kind | Documented delivery and access | Reviewed |
|---|---|---|---|
| Biohub Platform (external site: biohub.ai) | Hosted model API | Web tools and an API at biohub.ai for running ESMC, ESMFold2, and ESM3 and for browsing the ESM Atlas; API tokens are created in a developer console. Biohub describes the platform as freely accessible, with guardrails that restrict keywords and sequences associated with controlled pathogens and toxins.562 | Sep 29, 2026 |
Cataloged artifacts
Model families
Model releases
- ESM3 open small (esm3-sm-open-v1)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
- ESMC 6B (ESM Cambrian)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
Notable documented facts
- On November 6, 2025, Biohub announced that the team at EvolutionaryScale, a public benefit company that developed the ESM3 and ESM C protein models, would join Biohub. EvolutionaryScale's website now states that it is part of Biohub, and the ESM GitHub repository and model repositories are published under Biohub accounts.186
- In the same November 2025 announcement, Biohub said it was making three models (VariantFormer, CryoLens, and scLDM) freely available on its virtual cells platform.1
In the news
White House science summit lists industry partners in the Genesis Mission Consortium
On October 8, 2026 the White House published a fact sheet on science initiatives announced at its "Science: A New Golden Age" summit. It says eleven industry partners committed SI-for-science tools and compute credits to the Genesis Mission Consortium, and names NVIDIA, AMD, OpenAI, Anthropic, Google, AMP, Emerald AI, AWS, Armada, Crusoe, and Micron. The same fact sheet says NIH, DOE, and Biohub launched a virtual biology initiative to build data and models for virtual cells. The fact sheet describes announcements and commitments rather than an executive order.
Biohub's esm 3.4.0 package adds full support for ESMC and ESMFold2
Biohub published version 3.4.0 of its esm Python package on August 27, 2026. The release notes say it adds full support for ESMC and ESMFold2, a test suite for both, and a compatibility layer for the Hugging Face ports of ESMC and ESMFold2, while maintaining support for legacy model weights. Biohub's Hugging Face organization hosts ESMC-6B-hf, whose model card describes ESMC as a protein language model, says the ESMC 6B model has 6 billion parameters, and says Biohub is releasing source code and model weights for ESMC 6B, ESMFold2, and ESMC sparse autoencoders. The repository README says the models are available under the MIT license. USASI has not tested this release.
U.S. eligibility
Eligible · basis: U.S. nonprofit or lab
Biohub describes itself as a 501(c)(3) biomedical research organization, and its terms of use give a mailing address for Chan Zuckerberg Biohub, Inc. in Redwood City, California. The IRS exempt-organization extract for California lists Chan Zuckerberg Biohub Inc in Redwood City as a 501(c)(3) organization.249
Sources
This listing is not an endorsement or a federal approval.
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APA style
USASI. (2026, October 13). Biohub (Chan Zuckerberg Biohub). United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/companies/biohub/
BibTeX
@misc{usasi_biohub,
author = {{USASI}},
title = {Biohub (Chan Zuckerberg Biohub)},
year = {2026},
month = oct,
howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/companies/biohub/}},
note = {United States of America Superintelligence. Last updated 2026-10-13}
}The date is when this page was last updated. Add the date you read it if your style needs one.
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